Decentralized Finance
April 6, 2022
Updated
July 28, 2025

Infographic: DeFi, ReFi, and DeSci - Breaking Down the Acronyms

By:
Tereza Bizkova & Drew Simon
Explore the differences between DeFi, ReFi, and DeSci in this quick and accessible guide for Web3 newcomers. Learn how decentralized finance, regenerative finance, and decentralized science are leveraging blockchain and crypto rails to transform money, climate action, and scientific research. Featuring real-world examples like Aave, Regen Network, and AthenaDAO.

DeFi, ReFi, DeSci - Breaking Down the Acronyms

What they are, and why they matter

DeFi (Decentralized Finance)

Decentralized Finance refers to blockchain-based systems that enable peer-to-peer financial services like saving, lending, stablecoin payments, and insurance, without centralized intermediaries.

Examples:

ReFi (Regenerative Finance)

Regenerative Finance uses web3 tools to support climate action, local resilience, and sustainable economies. Projects often focus on verifiable impact, on-chain carbon, and community governance.

Examples:

DeSci (Decentralized Science)

Decentralized Science aims to democratize research by improving funding, access, and collaboration. Using blockchain, it enables open data, transparent grants, decentralized IP, and community-led discovery.

Examples:

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